Comparison of glomerular filtration rate by various methods among potential kidney donors of patients with end-stage renal disease

Abstract

Evaluation of GFR is one of the prime components of the donor evaluation. It helps in assessment of risks of kidney disease among the potential donors. Selecting donors with minimal long-term risk of kidney failure is important. Glomerular filtration rate can be affected by various factors like dietary protein intake, exercise, pregnancy, obesity, hyperglycemia, use of antihypertensive drugs, etc. Hence there is a need to assess the health of kidney of donors to ensure successful transplantation among end stage renal disease patients. A crosssectional study was undertaken to compare various methods to estimate Glomerular filtration rate (GFR) in 60 potential kidney donors who are either first degree relative/spouse of ESRD patients in the Department of Nephrology at Osmania General Hospital from January, 2017 to January 2019. The mean age of the study population was 42 ± 11.5 years and mean serum creatinine was 0.83 ± 0.1 mg/dl. The mean GFR as measured by Diethylene Tri amine Penta Acetic acid (DTPA) was 90.6 ± 11.1 ml/min/1.73 m2 . The estimated glomerular filtration rate (GFR) as per creatinine clearance method and Chronic Kidney Disease Epidemiology (CKD-EPI) Creatinine equation was found to be 97.8 ± 21.4 and 93.6 ± 18.1 ml/min/1.73 m2
respectively.
Conclusions: Estimation of GFR is better by creatinine clearance method and CKD-EPI Creatinine equation method