Dynamics of the Microbiological Scape and Antibiotic Susceptibility in Intensive Care Unit Patients

Abstract

The papers deal with a problem of decrease of antibiotic resistance by the introduction of proposed prevention and control complex in the intensive care unit. Data from 1111 bacteriological analyses taken from patients, who got treatment in the period from January to August 2015 (group 1) and the same period of 2018 (group II), were included in the study. The
complex included: measures for the prevention of antibiotic resistance spread and rational antibiotic use. Resistance to imipenem changed the most. The last increased by 60% (р≤0,05), which consisted of Ps. Aeruginosa isolates for 100%. A decrease in 39% of polyresistant clinical isolates of Klebsiella pneumonia in patients of I and II have important prognostic values. A complex of proposed measures included the division of patients in blocks according to the risk of infectious complications, control of antibiotics administration, adherence to sanitary norms by ICU staff, use of sodium hypochlorite lead to the decrease of pathogenic isolates and level of antibiotic resistance to specific groups of antibacterial drugs