Post-operative analgesia of Butorphanol and Buprenorphine with levo-bupivacaine in Transversus Abdominis Plane Block in lower abdominal surgeries: A randomized triple blind controlled trial

Abstract

Introduction:The ultrasoundguidedTAP blockisanalternateand more modern technique for post-operative analgesia following lower abdominal procedures. Various adjuvants including opioids are being used along with local anaesthetics to prolong analgesic efficacy, in TAP block.
Aim: To compare two drugs in terms of duration of analgesia and time of first request for analgesia.
METHODS: This was a randomized triple-blind controlled study which was carried out in 84 patients, 18-60 years of age of both sexes posted for lower abdominal surgery. Patients were randomly divided in two groups, each comprising 42. Group A received 20ml of 0.25% levo- bupivacaine + 0.3mg (1ml) buprenorphine and Group B received 20ml of 0.25% levo-bupivacaine + 1mg (1ml) butorphanol. Patients wereassessedforpain byVASand any sideeffectsat intervals of 30 minutes, 2 hours, 4, 6, 8, 12, 24 hours. . A chi-square test was performed to find associations in different variables between the 02 groups and student independent t-test was performed to find significant differences in mean in different variables between the two groups.
RESULTS: The study groups were comparable in demographic data such as age, sex, weight and ASA grades and it was found that there were no significant difference in age, gender, ASA Grade, weight, Heart rate, SBP, DBP, MAP, SPO2 among Group A and Group B.The mean Duration of analgesia and meantime of the first request of analgesia in GROUP A was 718.3±41.44minutesand725.33±40.68minuteswhileintheGROUP B was 442.6 ± 38.77 minutes and 448.2 ± 30.75 minutes. In comparison to GROUP B, GROUP A had a higher mean time for the initial request for analgesia and a longer mean duration of analgesia, and this difference was statistically significant.