STUDY OF ASSOCIATION BETWEEN GLYCOSYLATED HEMOGLOBIN AND ITS CLINICAL IMPLICATIONS IN ICU PATIENTS

Abstract

Background: HbA1c is a marker of long-term glycemic control in patients with diabetes mellitus (DM) and allows clinicians to estimate the recent mean blood glucose concentration
of a patient. In present study, we aimed to study association between glycosylated
hemoglobin and its clinical implications in ICU patients at a tertiary hospital. Material and
Methods: Present study was single-center, prospective, observational study, conducted
patients of age above 18 years old, admitted to medical intensive care unit (ICU). We divided
patients into two separate subgroups as patients with HbA1c < 6.5% & patients with HbA1c
≥ 6.5 %. Results: 137 patients (68.5%) have HbA1c < 6.5 and 63 patients (31.5%) have
HbA1c≥ 6.5%. Amongst the 200 cases admitted in ICU, 157 (78.5%) patients are nondiabeticand43 (21.5%) patients are known cases of diabetes. Majority of patients 118 (59%)
admitted in ICU were male and 82 (41%) were female. The association between glycosylated
hemoglobin and length of stay in ICU is statistically not significant. (p =0.872). 93 (46.5 %)
patients from group HbA1c < 6.5 % and 47 (23.5 %) patients from HbA1c > 6.5% group
needed mechanical ventilation. The association between glycosylated hemoglobin and
incidence of need of mechanical ventilation in ICU is statistically not significant. (p=0.33)
The association between glycosylated hemoglobin and number of days on mechanical
ventilation in ICU is statistically not significant (p=0.919). 33 (16.5 %) patients from group
HbA1c < 6.5 % and 17 (8.5 %) patients from HbA1c > 6.5% group needed hemodialysis. The
association between glycosylated hemoglobin and incidence of hemodialysis in ICU is
statistically not significant (p =0.66). Conclusion: The present study does not reveal
significant finding between glycosylated hemoglobin with various clinical aspects and
outcome like mortality, need of mechanical ventilation and hemodialysis in critically ill
patients.