To evaluate the effect of hypothyroidism on the renal functions of the body

Abstract

Introduction: The interactions between thyroid gland and renal functions are known for
years. Thyroid dysfunction can affect renal physiology and development, and on the other
hand, kidney disorders can influence thyroid function. Hence; the present study was done to
evaluated the effect of hypothyroidism on the renal functions of the body
Material and Methods: This one-year observational prospective study will be conducted in
the Postgraduate Department of Internal Medicine, Government Medical College and
Hospital, Jammu with effect from November, 2019 to October, 2020. Recording of detailed
history including history of cardiovascular disease, diabetes mellitus, hypertension, surgery,
or any drug intake and family history of renal, muscular, liver disorders.Measurement of
anthropometric indices like weight, height, BMI.Recording of vital signs.Blood
investigations including serum uric acid, serum creatinine, fT3, fT4 and TSH. The statistical
analysis was done using (SPSS 22.00 for windows; SPSS inc, Chicago, USA).
Results: In both the groups, females were comparatively more as compared to males. When
mean creatinine and Uric Acid (mg/dl) was compared statistically among case and control
group, it was found to be statistically significant as p<0.05.Positive significant correlation
was found between TSH and creatinine (r=0.54, p=<0.01) and and uric acid (r=0.61,
p=<0.01).
Conclusion: This study confirms that hypothyroidism is associated with a consistent
elevation in the serum creatinine and uric acid levels. Therefore, we would suggest
assessment of thyroid function in patients presenting with deranged renal function.