Habitual short sleep duration and circulating endothelial progenitor cells

Abstract

Chronic short sleep duration has been linked to endothelial dysfunction and increased risk of cardiovascular disease, Circulating endothelial progenitor cells (EPCs) are vital to endogenous vascular repair processes and cardiovascular health. We tested the hypothesis that habitual short sleep duration is associated with impairment in EPC number and function. C'ell with phenotypic EPC characteristics were isolated from 37 healthy, sedentary adults: 20 with normal sleep duration (13M/7F, age 59+1 years, sleep duration: 7,7+0.1 h/night) and 17 with short sleep duration (9M/8F: 5642 усari; 6.040.2 h/ight) EPC number was assessed by flow cytometric analysis of the percentage of peripheral blood mononuclear cells negative for CD45 and positive for CD34, VEGFR-2, and CD133 antigens