Evaluation of the Relationship among Survivin and Some Biochemical Markers in Women with Breast Cancer
DOI:
https://doi.org/10.48047/Keywords:
Survivin, breast cancer, glutathione, glutathione peroxide, malondialdeyde .Abstract
The present study was conducted on a group of women with breast cancer (60 women) and a group of healthy women as a control group (30 women) aged (27-85) years. Samples were collected from women with breast cancer from the Teaching Oncology Hospital - Medical City, Baghdad for the period from the first of October 2023 until the end of February 2024. The activity of servivin was asses and the level of glutathione, glutathione peroxidase, malondialdehyde and the following results were obtained:
1-There was a significant increase in the group of breast cancer women for both servivin,
and malondialdehyde compared to the control group.
2- There was a significant decrease in the level of glutathione-and glutathione peroxidase .
3-The existence of a significant correlation between survivin and each of GSH and GPX.
Conclusions: The results of the present study showed a significant increase in the level of survivin in women with breast cancer in conjunction with a significant correlation with GSH, GPX, MDA and BMI, which supports the possibility of considering survivin as an indicator for breast cancer diagnosis.
