A CASE OF IMMUNE MEDIATED NECROTIZING MYOPATHY

Abstract

Background: Immune-Mediated Necrotizing Myopathy (IMNM), one of the Inflammatory Myopathies, is a rare, thought to be complement-mediated muscle disease. IMNM can present much like polymyositis and causes muscle cell death (necrosis) that leads to weakness of the skeletal muscles on both sides of the body (symmetrical), commonly those closest to the body’s core (proximal), such as the hips, thighs, upper arms, shoulders, and neck. Muscle weakness, which is often severe, can develop over a period of days, weeks, or months. Specific Antibodies - Anti SRP and Anti HMGCoA reductase antibodies-Presence of aniti SRP antibodies shows relatively refractory course, Aggressive, More difficult to treat, aggressive immunotherapy required.
Method: A Case of middle aged female presented with bilateral proximal myopathy taken detailed study and laboratory investigations done
Discussion: A 47 year old female presented with B/L Symmetrical muscle weakness insidious in onset, proximal more than distal, lower limb more than upper limb with Anti SRP ab positive suggestive of Immune mediated necrotizing myopathy.