Inducible clindamycin resistance among clinical isolates of Staphylococcus aureus in a tertiary care hospital.
DOI:
https://doi.org/10.48047/Keywords:
Inducible Clindamycin resistance, D test, inducible MSLB phenotype, constitutive MSLB phenotype, MS phenotype, MRSA, Staphylococcus aureus.Abstract
Background: Staphylococcus aureus stands as a prominent cause for both nosocominal and
community acquired infections across the globe. Clindamycin, a member of MLSB family, has emerged as the preferred choice for treating Staphylococcus aureus infections. However, one critical consideration in administering Clindamycin is the potential development of inducible Clindamycin resistance, posing a significant risk of clinical treatment failure.
Aim: The study was aimed to determine the occurence of inducible Clindamycin resistance among Staphylococcus aureus isolates in our geographic region.
Method: The hospital based cross sectional study was conducted over a period of one year from January 2023 to December 2023. A total of 672 Staphylococcus aureus isolates were
identified by conventional methods and subjected to antimicrobial susceptibility test by Kirby
Bauer disk diffusion method and Erythromycin resistant isolates were tested for D test.
Result: Out of 672 Staphylococcus aureus isolates, 517 were MRSA and 155 were MSSA.
Erythromycin resistance was seen in 395 (58.77%) isolates. D test revealed inducible
clindamycin resistance in 45 (6.69%) isolates, constitutive clindamycin resistance in 91
(13.54%) isolates and MS phenotype in 259 (38.54%) isolates. Inducible clindamycin
resistance was more in MRSA (7.73%) isolates compared to MSSA (3.22%) isolates.
Conclusion: D test is a simple and cost-effective test that should be performed as routine
laboratory test and will help in guiding the clinicians regarding judicious use of Clindamycin
