Thyroid Dysfunction in PCOS and Non PCOS Women – A Tertiary Care Cross Sectional Study
DOI:
https://doi.org/10.48047/Keywords:
PCOS – Polycystic Ovarian Syndrome, SCH – Subclinical hypothyroidism, TSH – Thyroid Stimulating Hormone, Infertility, Hypothyroidism, Rotterdam CriteriaAbstract
BACKGROUND
Thyroid disorders and polycystic ovary syndrome (PCOS) are the most common endocrine
conditions in the general population. PCOS is characterised by various menstrual and hormonal irregularities culminating in anovulation, infertility, and hyperandrogenism. PCOS is viewed as a heterogeneous disorder of multifactorial aetiology also associated with increased metabolic and cardiovascular risk factors. Both PCOD and thyroid dysfunction have multiple common presentations and both have profound effect on fertility and reproductive biology. In patients with PCOS, thyroid dysfunction can worsen the existing insulin resistance, leading to higher levels of androgens and cardiovascular disorders.
AIM
To determine the association between thyroid function profile of patients with Polycystic Ovary Syndrome (PCOS) and to compare it with healthy women.
MATERIALS AND METHODS
This is a cross-sectional study on 80 patients with PCOS at Sri Siddartha medical centre, over
a period of 6 months. In this study, PCOS was diagnosed based on Rotterdam criteria and
patient details regarding history, physical examination and thyroid profile were obtained. In all
these patients, thyroid profile, age, BMI, W/H ratio, Clinical hirsutism and Menstrual
abnormalities were studied.
RESULTS
PCOS was more common in the age group of 26-30 years. The women in group P were found
to have a higher BMI as compared to women in Group H, and the difference was found to be
statistically significant (p=0.0065). The mean TSH level in PCOS was found to be higher than Non PCOS, and the difference was found to be statistically significant (p<0.001).20 % of PCOS
patients diagnosed to have hypothyroidism, 15% patients found to have Sub-clinical
hypothyroidism and rest 80 % were euthyroid. 63% of PCOS patients with hypothyroidism
presented with complaints of irregular menstrual cycle, 26% with complaints of infertility and
11% with other complaints.
CONCLUSION
The prevalence of subclinical hypothyroidism was found to be significantly high in women
with PCOS. Periodic testing can reduce the likelihood of additional health issues and improve
overall well-being.
