A study of Serum Vitamin D and Vaspin Levels among patients with Acute Myocardial Infraction

Abstract

Background : Acute Myocardial Infarction (AMI) is a major cause of morbidity and mortality worldwide. Emerging evidence suggests that vitamin D deficiency and adipokines like vaspin play significant roles in the pathophysiology of cardiovascular diseases. However, the relationship between serum vitamin D levels, vaspin levels, and AMI remains poorly understood. Aim and Objectives : To evaluate and compare serum vitamin D and vaspin levels in patients with AMI and healthy individuals.
Materials and Method : This cross-sectional study involved 100 participants, divided into two groups: 50 patients diagnosed with AMI and 50 age- and sex-matched healthy controls. Serum levels of vitamin D and vaspin were measured using enzyme-linked immunosorbent assay (ELISA) techniques. Clinical and demographic data were collected and analyzed. Statistical analysis was performed to compare serum levels between the two groups and to evaluate the correlation between vitamin D and vaspin  levels. Results : The results showed that serum vitamin D levels were significantly
lower in AMI patients compared to controls (p<0.05). Conversely, serum vaspin levels
were significantly higher in the AMI group (p<0.05). Conclusion : The study concludes
that lower vitamin D levels and elevated vaspin levels are associated with AMI. These
biomarkers may serve as potential predictors for the risk and severity of AMI, offering
new insights into the pathogenesis and potential therapeutic targets for cardiovascular
disease management. Further research is warranted to explore the underlying
mechanisms and clinical implications.