ADVANCES IN PEDIATRIC RESUSCITATION: GENETIC PROFILING AND PERSONALIZED MEDICINE APPROACHES

Abstract

Background: Pediatric resuscitation presents unique challenges due to the diverse responses
children exhibit to standard emergency interventions. Recent advancements in genetic profiling and personalized medicine have shown promise in tailoring resuscitation efforts to
individual genetic backgrounds, potentially enhancing outcomes. Objectives: This study
aims to evaluate the efficacy of genetic profiling and personalized medicine strategies in
improving the success and outcomes of pediatric resuscitation. Methods: A cohort of 120
pediatric patients requiring resuscitation was studied at a tertiary care center. Participants
were divided into two groups: one receiving standard resuscitation protocols and the other
receiving interventions based on genetic profiles. Data on resuscitation success, complication
rates, hospital stay length, and 30-day survival rates were collected and analyzed using odds
ratios and confidence intervals. Results: Patients in the personalized medicine group showed
a significant improvement in resuscitation success (80% vs. 60%, p=0.011) and 30-day
survival rates (90% vs. 75%, p=0.011) compared to the standard care group. Furthermore,
there were notable reductions in complication rates and hospital stay lengths. Genetic
markers related to drug metabolism and stress responses were identified as significant
predictors of resuscitation outcomes. Conclusion: The implementation of genetic profiling
and personalized medicine in pediatric resuscitation significantly enhances clinical outcomes.
These findings underscore the potential of these approaches to transform pediatric emergency practices by providing more targeted and effective interventions.