STABILITY CONSIDERATIONS IN EXTEMPORANEOUSLY COMPOUNDED PREPARATIONS FROM COMMERCIALLY AVAILABLE PRODUCTS FOR PEDIATRIC POPULATIONS

Abstract

When commercially accessible, licensed, and age-specific dosage forms are not available, pharmacists can create
appropriate pharmacological compositions through a process known as "extemporaneous compounding." These preparations carry a lot more risk than using
prescription medications. One of the main things to consider while preparing impromptu formulations is stability. The purpose of this work was to analyze all of
the existing stability studies in order to investigate the stability of pediatric extemporaneous formulations of standard solid dosage forms that are sold in the market. Approach. The Web of Science, PubMed, Scopus, EMBASE, Cochrane Library, and Google Scholar databases were searched for articles. Based on the
inclusion criteria, a total of 28 experimental trials documenting the stability of oral pediatric extemporaneous formulations were selected from all of the searched papers. Oral spontaneous formulations
using pure pharmaceuticals and commercially accessible dose forms were taken into consideration.