STUDY OF EFFECT OF PRIMING OF PROPOFOL ON HAEMODYNAMIC CHANGES DURING INTUBATION

Abstract

Background: Propofol auto co-induction or the Priming Principle has also been proposed to
lower Propofol requirements. The purpose of this study was to see if using the ‘Priming Principle’ for the propofol induction, 2 minutes before actual induction would attenuate the
pulse rate to laryngoscopy and intubation, as opposed to the reflex tachycardia due to
increased sympathetic activity. Material and Methods: Present study was Comparative,
randomized, prospective, observational study, conducted patients belonging to age groups 18-
35 years, to either gender, belonging to ASA physical status 1 and 2, scheduled for elective
surgical procedures requiring general anaesthesia with endotracheal intubation. Patients were
randomly allocated into two groups of 25 each and were subjected to the Group A (priming
of propofol with 25% of the calculated dose) & Group B (No priming of propofol). Results:
In the group that was administered with primed dose of propofol it was noted that the
administered dose was much less compared to the originally calculated dose. The dose of
propofol that was administered in the primed group was much less compared to the control
group with a statistical difference having a P value of 0.00. The pulse rate at 1 minute post
laryngoscopy and intubation in the case group was lower than that of the control group with
the p value of 0.010. The SBP was higher in cases when compared to controls with statistical
significance. The p values at laryngoscopy, post laryngoscopy and intubation at 1-,3-
and 5 minutes are 0.000, 0.000, 0.000 and 0.001 respectively. Conclusion: Priming of
propofol with 25% of the calculated dose two minutes before the induction is effective in
attenuating the pulse rate at 1 minute post intubation. The group with priming required doses
lesser than the calculated dose with better hemodynamic stability.