Influence of Serum albumin on HbA1C and HbA1c defined Glycemic Status: A Retrospective study in GGH ,Anantapur

Abstract

Background: The interplay between serum albumin levels and HbA1c-defined glycemic status
in individuals with diabetes is critical for understanding the metabolic and clinical outcomes
of glycemic control. This study aims to investigate the correlation between serum albumin and
HbA1c levels to elucidate their relationship and potential implications for diabetic
management.
Methods: A retrospective study was conducted involving 100 diabetic patients attended
General medicine OPD,GGH Anantapur . Serum albumin and HbA1c levels were measured
using standard biochemical methods. Patients were categorized into three groups based on their HbA1c levels: good glycemic control (HbA1c < 7%), moderate glycemic control (HbA1c 7-
8%), and poor glycemic control (HbA1c > 8%). Statistical analysis was performed to evaluate
the correlation between serum albumin and HbA1c levels across these groups.
Results: The study revealed a significant inverse correlation between serum albumin and
HbA1c levels (r = -0.45, p < 0.001). Patients with poor glycemic control exhibited significantly
lower serum albumin levels compared to those with good and moderate glycemic control. The
mean serum albumin levels were 4.2 ± 0.3 g/dL in the good glycemic control group, 3.8 ± 0.4
g/dL in the moderate glycemic control group, and 3.5 ± 0.5 g/dL in the poor glycemic control
group.
Conclusion: Our findings suggest a significant inverse correlation between serum albumin and HbA1c levels in diabetic patients, indicating that lower serum albumin levels are associated with poorer glycemic control. Monitoring serum albumin levels alongside HbA1c could provide additional insights into the metabolic status and guide more effective management strategies for individuals with diabetes. Further research is warranted to explore the underlying mechanisms and potential therapeutic implications of this relationship.