STUDY TO ASSESS THE ARTERIAL BLOOD GAS ANALYSIS AS A PROGNOSTIC PREDICTION TOOL IN ORGANOPHOSPHORUS COMPOUNDS POISONING PATIENTS

Abstract

Background: Organophosphorus compounds are frequently used insecticides in agriculture.
suicidal ingestion of Organophosphorus Compound has been common because it is easily accessible and widely used. Morbidity and mortality from acute Organophosphorus poisoning
are attributed to respiratory failure which can be detected early by ABG. The aim of our study
was to assess the Arterial blood gas analysis as a prognostic prediction tool in Organophosphorus compounds poisoning patients. Material and Methods: Present study
was single-center, prospective, observational study, conducted in patients of age of more than
18 years, Consumption of OPC as per patient or attenders’ history or as an evidence compound, Clinical features suggestive of OP poisoning. Results: Out of 102 patients, 27.5%
had normal ABG, 22.6% had Metabolic acidosis, 18.6% had Respiratory acidosis, 28.4% had
Respiratory alkalosis and 2.9% had Metabolic alkalosis. Out of 29 patients who did not
require ventilatory support, 86% had normal ABG. Those who required ventilator, 37% had
Respiratory alkalosis, 31.5% had Metabolic acidosis and 24.7% had Respiratory acidosis.
Mean Duration of ventilator support in days was highest in Metabolic acidosis (6.3) group
followed by Respiratory acidosis (4.3) and Respiratory alkalosis (4.3) and least in those with
normal ABG findings (1). The difference in duration of ventilator support across the groups
was statistically significant. Duration of ICU admission in days was highest in Metabolic
acidosis (10.8) followed by Respiratory acidosis (8.6) and Respiratory alkalosis (8) patients.
The difference in ICU stay across the groups was statistically significant. Conclusion: The
present study highlights the importance of initial Arterial blood gas estimation performed on
patients presenting with OP poisoning as an effective tool in the quick assessment of
prognosis.