An observational study to evaluate the potential of Serum Uric Acid as a predictive marker for diagnosing Gestational Diabetes Mellitus during the first trimester

Abstract

Introduction: - The presence of elevated uric acid levels during pregnancy has been found to be associated with a higher risk of unfavourable outcomes, including gestational diabetes mellitus. This study seeks to investigate the hypothesis that an increase in uric acid levels during the first trimester of pregnancy is linked to the development of gestational diabetes in later stages.
Material and Methods: - In this study, all pregnant women under 12 weeks of gestation were enrolled after providing informed consent. Blood samples were obtained for serum uric acid analysis, and these individuals were subsequently monitored with an oral glucose tolerance test between twenty-four and twenty-eight weeks of pregnancy.
Results: - The average age of expectant mothers was 29.84 ± 4.94 years. The average height and weight were 151.52 ± 7.49 cm and 50.60 ± 6.88 kg respectively. The body mass index of the participants was 22.13 ± 3.31 kg/m2. The average gestational age of pregnant women was 11.14 ± 1.30 weeks. The average uric acid level was 3.81 ± 1.24 mg/dl. The chi-square test yielded a significant p value of 0.018 in this research study.
Conclusion: - Elevated uric acid levels during the initial trimester can serve as a dependable indicator for forecasting the development of gestational diabetes mellitus during subsequent stages of pregnancy.