STUDY OF CARDIAC BIOMARKERS IN CHRONIC KIDNEY DISEASE PATIENTS IN A TERTIARY CARE CENTRE

Abstract

Background: There has been increasing evidence of association between cardiovascular and
chronic kidney disease. Most of complications and mortality in these patients are due to
development of cardiovascular disease (CVD) rather than due to chronic kidney disease (CKD)
by itself. Though cardiac biomarkers are available but due to lack of clinical symptoms in early
stages and delayed diagnosis mortality rate has increased. The present study was conducted to
detect the cardiovascular dysfunction measured by various cardiac biomarkers like serum
Cardiac high sensitivity Troponin I, Creatinine kinase and creatinine Kinase MB with eGFR in
CKD patients to correlate the association of cardiovascular dysfunction in patients with CKD for
early detection and initiation of aggressive treatment to reduce mortality.
Methods: The present cross-sectional study was conducted on 110 patients of chronic kidney
disease (CKD) at tertiary care hospital, Hyderabad. Cardiac HS Troponin I, Creatine Kinase
(CPK) and Creatine Kinase- MB (CK-MB) were analysed and correlated with e-GFR, Urea and
creatinine levels.
Results: There was statistically significant association between Hs Troponin I, CK-MB and CPK
with Chronic kidney disease. There was negative corelation of cardiac biomarkers with eGFR
and positive correlation with Urea and creatinine. Multivariate regression analysis for predictors
of cardiac dysfunction was done using ANOVA with renal parameters in patients with CKD
which showed strong association between e-GFR and cardiac markers.
Conclusion: High morbidity and mortality in patients with CKD is observed due to
Cardiovascular disease. It is important to diagnose CVD with high index of suspicion and
evaluate with commonly available biochemical cardiac markers. In our study there was
significant elevation in Hs Trop I, CK MB and CPK in CKD patients which correlated negatively
with eGFR. Routine use of these markers during follow-up of CKD patients helps in risk
assessment, prevention of complications and timely interventions.