Effects of chronic oral sodium benzoate on glucose homeostasis using adult mice as experimental models

Abstract

Introduction: Sodium benzoate (NaB) is a widely used food preservative and antimicrobial substance. Sodium benzoate is a major preservative in soft drinks. Large scale consumption of soft drinks is a risk factor for T2DM. Studies have shown that sodium benzoate decreases leptin levels which can lead to diabetes mellitus. Since studies exploring the effects of chronic oral sodium benzoate on models of glucose homeostasis are lacking, we intend to evaluate and compare the effects of chronic administration of sodium benzoate on glucose homeostasis in experimental models of adult mice. Materials and methods: The study