Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population

Abstract

Researchers have determined that Indians face a higher risk of heart disease, despite the fact that 
nearly half of them are vegetarians and lack many of the other traditional risk factors. In the below-30 age group, 
coronary artery disease mortality among Indians is three-fold higher than in the whites in United Kingdom and 
ten-fold higher than the Chinese in Singapore. High levels of homocysteine have been widely linked to the early 
onset of heart diseases in other populations, although a definite proof among Indians is lacking, which needs to be 
investigated by way of screening for factors responsible for high homocysteine level