Reduced nitrate level in individuals with hypertension and diabetes

Abstract

Nitric oxide (NO) turnover is vital for proper endothelial function to maintain a healthy vascular 
system. Various risk factors responsible for hypertension and diabetes may disrupt this homeostasis, leading to 
decreased bioavailability and/or bioactivity of NO, which potentiates endothelial dysfunction. Plasma NO is a 
useful indicator of NO homeostasis and vascular endothelial function. Since endothelial function plays a key 
role in the development and progression of diseases like diabetes and hypertension, we sought to investigate 
the NO profile in patients having diabetes and hypertension and determine the relationship of NO turnover 
with the disease