A PROSPECTIVE STUDY: ANTIOXIDANT STATUS IN RELATION TO LIPID PEROXIDATION AND BIOCHEMICAL PARAMETER IN AFFECTED WOMEN WITH BREAST CANCER

Abstract

Background – Breast cancer is the most common type of cancer that affects women’s life.
Many causes have been implicated in the development of cancer such as diet, obesity,
environmental factors, family history and many more. The objectives of the study to rule out
the correlation between the antioxidant status and lipid peroxidation with biochemical
parameters in breast cancer patients as compare to the healthy groups.
Methods – The prospective study including 76 women who were grouped into two equal
groups (38 breast cancer patients as case and 38 as a healthy control). Serum antioxidant
enzymes (SOD, CAT, glutathione) and degree of lipid peroxidation (MDA) were estimated by
kit method. In addition we evaluate the biochemical parameters by automated analysers.
Result can be expressed as mean ± S.D with a 95% confidence interval. Statistical analysis is
done by student’s t-test using SPSS 20.0. Significant value were be considered as P<0.05.
Result – MDA level were highly significant in the breast cancer patients as compare to
healthy control (P<0.05). Compared to healthy group, the antioxidant enzymes (Glutathione,
SOD and CAT) activity were significantly decreased in breast cancer patients (P<0.05). On
the other hand serum LDH, ALP, Uric acid, and GGT were found significantly increased in
breast cancer patients as compared to healthy control (P<0.05).
Conclusion – Oxidative stress plays an important role in development and progression of
breast cancer. We concluded that the biochemical parameters and antioxidant enzyme along
with MDA as an important diagnostic tool in the disease monitoring and treatment. Further
studies in future on it may more helpful for treatment and management of breast cancer.