The HPA-Plasticity Feedback Loop, Interactions Between Neuroplasticity, Borderline Personality Disorder, and the HPA-Axis: A Systematic Review

Abstract

Borderline personality disorder is characterized by heightened sensitivity to rejection, unstable
interpersonal relationships, self-image, emotions, and behaviors. 1-2% of the population is
associated with higher rates of comorbid psychiatric pathology and significant rates of suicide
(10%). Recent studies have suggested that high levels of cortisol in individuals with borderline
personality disorder result in altered glucocorticoid receptors, significant cortical reduction, an