Prevalence and Antimicrobial Resistance Patterns of Enterococcus spp. with Special Reference to Vancomycin-Resistant Enterococci in Clinical Isolates from a Rural Tertiary Care Hospital in Indore, Central India.

Abstract

Introduction- Vancomycin-resistant enterococci (VRE) are opportunistic pathogens known to cause a wide range of clinical 
infections. Globally, VRE have emerged as a significant concern in healthcare settings, particularly among hospitalized patients, 
and have been implicated in numerous nosocomial outbreaks. The primary mechanism underlying vancomycin resistance in 
enterococci is the alteration of peptidoglycan precursors, which leads to reduced binding affinity for glycopeptide antibiotics, 
thereby diminishing their therapeutic efficacy.