EXPLORATION OF ANTI-HYPERGLYCEMIC POTENTIAL OF AERVA SANGUINOLENTA (L.) BLUME ON STZ INDUCED DIABETIC RATS.
DOI:
https://doi.org/10.48047/Keywords:
Diabetes, Aervasanguinolenta, Flavonoids, Poly phenol, Antioxidant. Tannins.Abstract
Aervasanguinolenta (L) (Amaranthaceae), commonly known as Blume in India and its native place. Objective: To evaluate the hypoglycemic activity of methanol extract of A.sanguinolentai.e MEAS leaves in streptozotocin (STZ)-induced diabetic Wistar
rats. Materials and Methods: In rats fed with HFD for 4 weeks, hyperglycemia was induced by single intraperitoneal injection of STZ (50 mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with MEAS orally at the doses of 100 and 200
mg/kg b.w. daily for 14 days. Glibenclamide (0.5 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every 3, 7, 10 and 14th day during the 15 days of treatment. Serum and hepatorenal biochemical parameters were estimated.
