To Study Secretory Senescence profile in Serous Effusion

Abstract

Background: Serous effusions accumulations of fluid in pleural, peritoneal, or pericardial cavities represent a significant clinical challenge with diverse etiologies ranging from benign inflammatory conditions to malignancies. Cellular senescence, characterized by stable cell cycle arrest and the senescence-associated secretory phenotype (SASP), has emerged as a critical mediator of chronic inflammation and tumor progression. This study aimed to characterize the secretory senescence profile in serous effusions and evaluate its diagnostic utility in differentiating malignant from benign etiologies.