The Role Cardioprotective of Edible Bird’s nest (Collacalia fuciphaga) Extract Through Suppression of Oxidative Stress

Abstract

Background: Heart organs can be damaged due to an increase in free radicals that are not balanced by
antioxidants. Edible Bird’s Nest (Collocalia fuciphaga) contains many amino acids and vitamins that are thought to
stimulate antioxidant activity. The cardioprotective nature of swallow's nest is expected to be the basis of
management for cases of heart disease.
Methods: The design of this study is experimental . This study showed levels of MDA (free radical
decomposition), catalase activity (endogenous antioxidants) and histology of heart tissue after bieng given edible
bird’s nest extract (doses 10, 20 and 40 mg/kgBW) for 32 days.
Results: Edible Bird’s extract was compared to the control: MDA levels decreased significantly (0.007; 0.038;
0.030 nmol/mg tissue), increased catalase activity (1.32; 1.21; 0.83 IU/mg tissue); Cardiomyocytes at 40x
magnification showed a normal nucleus in the center.
Conclusion: Edible Bird’s extract can suppress oxidative stress, through decreasing MDA, increasing catalase
activity, and normal cardiomyocyte histology.