Tumor necrosis factor-alpha G-308 A polymorphism and risk of coronary heart disease and myocardial infarction: A case-control study and meta-analysis

Authors

  • Hongxia Chu,#, Jun Yang,#, Shaohua Mi , Soumitra Sudip Bhuyan , Jun Li , Lin Zhong , Shaorong Liu , Zhigang Tao , Jianping Li , Hongying Chen Author

Keywords:

: Coronary heart disease, meta-analysis, myocardial infarction, polymorphism, tumor necrosis factor-alpha

Abstract

Objectives:7KHWXPRUQHFURVLVIDFWRUDOSKD 71)Į JHQHPD\SOD\DQLPSRUWDQWUROHLQFRURQDU\KHDUWGLVHDVH  &+' DQGP\RFDUGLDOLQIDUFWLRQ 0, ULVN5HFHQWO\FRQWURYHUVLDOUHVXOWVUHJDUGLQJWKHDVVRFLDWLRQRIWKH*
$ UV SRO\PRUSKLVPRIWKH71)ĮJHQHZLWK&+'0,KDYHEHHQUHSRUWHG:HKHUHLQH[DPLQHDSRVVLEOH DVVRFLDWLRQEHWZHHQWKH*$ UV SRO\PRUSKLVPRIWKH71)ĮJHQHDQG&+'0,LQDVDPSOHRIWKH Chinese Han population. Materials and Methods::HGHWHUPLQHGWKHJHQRW\SHVRI71)Į*$ UV  LQXQUHODWHG&KLQHVHSDWLHQWVZLWK&+'SDWLHQWVZLWK0,DQGFRURQDU\DUWHU\GLVHDVHIUHHFRQWUROV $GGLWLRQDOO\DPHWDDQDO\VLVRIDOOSUHYLRXVVWXGLHVRQWKH71)Į*$SRO\PRUSKLVPDQGWKHULVNRI&+'
and MI was performed. Results:$$JHQRW\SHVLQWKH*$ UV SRO\PRUSKLVPRIWKH71)ĮJHQHGLG QRWRFFXUPRUHIUHTXHQWO\LQ&+'0,SDWLHQWVWKDQLQFRQWUROVRGGVUDWLRV FRQ¿GHQFHLQWHUYDOV ZHUH
 WR IRU&+'DQG WR IRU0,DIWHUDGMXVWLQJIRUFRQYHQWLRQDOULVNIDFWRUV)XUWKHU
VWUDWL¿FDWLRQIRUDJHJHQGHUDQGRWKHUFDUGLRYDVFXODUULVNIDFWRUVGLGQRWDOWHUWKHSULRUQHJDWLYH¿QGLQJV3RROHG PHWDDQDO\VLVRIVWXGLHVDOVRIRXQGQRVWDWLVWLFDOO\VLJQL¿FDQWDVVRFLDWLRQVEHWZHHQWKH71)ĮSRO\PRUSKLVPDQG CHD/MI risk in the genetic additive, dominant, and recessive models. Subgroup analyses showed no association EHWZHHQWKH71)ĮSRO\PRUSKLVPDQG&+'0,LQ$VLDQDQG&DXFDVLDQSRSXODWLRQVConclusion: Our study VKRZHGQRDVVRFLDWLRQEHWZHHQWKH*$ UV SRO\PRUSKLVPRIWKH71)ĮJHQH SUHVHQFHRI$DOOHOH  DQG&+'0,LQWKH&KLQHVH+DQSRSXODWLRQ7KHUHZDVQRHYLGHQFHRIDGLIIHUHQFHLQULVNHIIHFWVRIUV
between Caucasians and Asians

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Published

2012-04-22

Issue

Vol. 3 No. 2 (2012): volume 3 issue 2 (2012)

Section

Articles