Investigation The Role Of Oral Candidiasis And IL 17 Gene Polymorphism Rs 2275913 In Type 2 Diabetes Mellitus In Iraqi Arab Patients.

Abstract

Type 2 diabetes mellitus is a major health concern distrusted globally and affected by several genetic
and immunologic factors. Oral fungi and cytokine gene diversity may also play a significant role. The
current study aims to investigate the association of oral candidiasis and IL-17A gene polymorphism
with T2DM in Iraqi Arab patients. 75 T2DM patients and from both genders were enrolled; in addition,
75 healthy people of matched age and sex were also considered a control. TETRA-ARMS-PCR, Vitik2
,
and ELISA techniques were used in this study. The results showed that the serum level of IL17A was
significantly higher in T2DM than in the control group (86.7 ± 20.0; p=0.002). The genetic results
showed that A allele of IL17A was slightly increased frequent (40%), GG VS AA+GA was significant
as an etiological genotype with patients (OR:3.36, IC:1.6- 6.7; p,0.006). In addition, Candida albicans
was the most frequent fungus isolated from T2DM patients. The current study is the first to diagnose
species with less frequent oral presence, including Cryptococcus neoformans, Candida ciferrii, and
Trichosporon spp.In conclusion, the present study indicated IL17A gene polymorphism rs 2275913
significantly affects developing T2DM. Moreover, increased levels of IL17A were identified as a
susceptibility marker of T2DM. And increased levels of IL17A for oral candidiasis patients.