Association of CDKN2B-AS1 Gene polymorphism with Acute Myocardial Infarction.

Abstract

Background and objectives: Several genetic studies have demonstrated an association between genetic
variants in a region on chromosome 9p21 and acute myocardial infarction. We aimed to investigate the
association between the cyclin-dependent kinase inhibitor 2B antisense RNA rs1333049 single nucleotide
polymorphisms on chromosome 9p21 and acute myocardial infarction, in addition to determine the
association between risk genotypes and 1- year outcome in such patients.
Methods: A total of 150 subjects (100 patients with acute myocardial infarction and 50 participants as a
controls) were enrolled in the study. All subjects underwent genotyping of rs1333049. Patients were
followed up for 1 year for development of reoccurrence of myocardial infarction, re-coronary intervention
and cardiovascular death.
Results: The frequency of the GC and CC genotypes of rs1333049 is higher in patients in comparison with
controls (54% vs 36% and 36% vs 18% respectively, p<0.001), while controls demonstrated increased
frequency of GG genotypes (46% vs 10%, p<0.001). In a multivariate logistic regression analysis. GC and
CC genotypes were independent risk factors for myocardial infarction (Odd`s ratio was 174.67, p=0.005).
New myocardial ischemic event was significantly higher among the carriers of the CC and CG genotypes
compared with patients with homozygous GG genotype (43.3% vs 10%, p value= 0.041).
Conclusion: Cyclin-dependent kinase inhibitor 2B antisense RNA rs1333049 single nucleotide
polymorphisms is associated with acute myocardial infarction. The carriers of the CC and CG genotypes
are at risk for new coronary events rather than homozygous GG genotype in 1 year follow up.