Comparative Study of Biochemical Markers Between COPD without CVD and COPD with CVD

Abstract

Background:COPD is a systemic disease; it causes various comorbidities. Cardiovascular
disease is also a important comorbidity due to COPD. Several biochemical parameters like
plasma/serum lipid, glucose, creatinine get derange in COPD.
Aim of the study: The aim of the study was to compare the changes in biochemical parameters
in COPD which causes cardiovascular disease also.
Materials and Methods: We investigated 109 confirmed COPD patients, between the age group
40 to 80 years. COPD was diagnosed by Spirometry by following GOLD guidelines.Lipid
profile, blood sugar and serum creatinine were investigated among all the patients. Then to
confirm the cardiovascular disease 2D echocardiography was done. Then two groups of the
patients were made patients having COPD without CVD and COPD with CVD. After that we
compared the lipid profile, blood sugar and serum creatinine between these groups.
Results: In this study, the number of COPD patients with moderate, severe, and very severe
COPD were 39, 50, and 20, respectively.On echocardiography 57 patients had normal
echocardiograph. While remaining 52 patients had cardiovascular diseases(PAH/dilated right
atrium or ventricle/ LVDD/low LVEF).39 of them had severe to very COPD.On comparison of
biochemical profile between COPD without PAH and COPD with PAH, dyslipidemia was found
in which significant differences were found in HDL cholesterol and VLDL cholesterol,while no
significant differences were found in other lipid profile test along with blood sugar and serum
creatinine.
Conclusion: Our study shows a high prevalence of cardiovascular disease in COPD patients.On
comparison between COPD with CVD and COPD without CVD,we found the dyslipidemia in
our study. A significant statistical difference was found of HDL and VLDL cholesterol.whereas
no significant difference were found at blood sugar and serum creatinine level.