Effects Of Salacia Reticulata Root Bark On Blood Glucose Levels Of Normal And Alloxan-Monohydrate Induced Diabetic Mice

Abstract

In the present study, a comparative antidiabetic potential of S. reticulata root bark ethyl acetate and aqueous
extracts were studied in vitro. Acute toxicity study of both extracts was carried out in male BALB/c mice,
showed no toxicity. Further, in in-vivo studies showed antidiabetic activity in mice with induced type II
diabetes mellitus. Type II diabetes mellitus was induced in the experimental rats by intraperitoneal injection
of 10% alloxan monohydrate (2,4,5,6 tetraoxypyrimidine; 5-6-dioxyuracil). The mice were orally fed
different doses ranging from 50 to 200 mg/kg body weight of S. reticulata root bark extracts for 8 hrs.
Blood glucose level, body weight and hematological parameters were analyzed on day 0, 7, 14 and 28 days.
Among these extracts, ethyl acetate extract showed decreased the glucose levels in a dose-dependent
manner as well as the hematological parameter levels in diabetic mice as compared with aqueous extracts.
The HPLC chromatogram showed the abundant presence of phenolic acids and terpenoids.