A Study Of Biochemical Profiling In Human Umbilical Cord Blood In Preterm And Term Neonates

Abstract

Background: The major causes of death both in developed and developing countries are diabetic mellitus,
jaundice, cardiovascular disorders and hyperbilirubinemia. Higher concentration of cord blood glucose,
urea, total protein and albumin in pre term neonates may increase their future risk of cardiovascular
diseases. Early diagnosis and dietary modifications and proper management may rectify the risk factors and
prevent future risk of disease. Our study aims to Study the biochemical profiling in human Umbilical cord
blood in preterm and term Neonates.
Methods: It is cross sectional observational study conducted for a period of one year from October 2019 to
November 2020 in the Departments of Biochemistry and Gynecology of KD Medical College, Hospital and
Research Center, Mathura & Santosh Medical College and Hospitals, Ghaziabad.
Results: Among 100 neonates including 50 (50%) term and 50 (50%) preterm, blood sugar, Total bilirubin,
direct and indirect bilirubin, Urea, Creatinine, uric acid, Total protein and albumin, were higher in preterm
as compared to term babies while Urea level was significantly increased (<0.05) in term as compared to
preterm babies.
Conclusion: There is inverse relationship between gestational age and different biochemical parameters
and this deranged biochemical profile preterm group could be a risk factor for future development of
diabetic mellitus, jaundice, cardiovascular disorders and hyperbilirubinemia diseases in their later part of
life.