Study the Efficacy of Antiemetic with Anesthesia on the Physiological Parameters Changes in German Shepherd Dogs

Abstract

Objectives: the purposes of the current study to evaluate the efficacy of antiemetic’s associated with 
anesthesia on the physiological parameters (rectal body temperature and rate of respiratory, heart and 
oxygen level) that occur as a result of injection of anesthetic agents, use of ondansetron and hyoscine 
as antiemetic before surgery as a premedication’s and then injection of the mixture of xylazine and 
ketamine intravenously to induce unconsciousness (general anesthesia). 
Methods: Fifteen healthy adult males from German shepherd dogs used in the current study that 
divided randomly into three groups. Drugs dosed of ondansetron (0.1mg/kg. b.w) and hyoscine (0.03 
mg/kg. b.w) with xylazine and ketamine (1.1mg/kg B.W, 2.2mg/kg B.W) respectively. All drugs were 
injected intravenously, the effects of the drug were studied on the physiological parameters at periods 
of zero time (base line) ,10 minutes after injection of antiemetic and 10 minutes after injection of 
anesthetic agents by using patient monitor for reading the physiological observation 
Results:the results showed that there were statistically significant decrease in the incidence of body 
temperature and respiratory rate during the period of anesthesia followed the injection of antiemetic 
agents for all groups to compare with no significant between groups at the level of (P< 0.05). In the 
observation of heart on patient monitor reveal in all groups significant decrease of the heart rate during 
the period of observation followed the injection of these agents but the other group (ondansetron group) 
reveal at the level of (P < 0.01) significant decrease after the injection of anesthetic agents and 
hyoscine group on the level (P < 0.05) was a significant decreasing.