Role of Curcumin Adminisration on Experimentally Induced Nonalcoholic Steatohepatitis (NASH)

Abstract

Background: The strong association of NASH with sedentary lifestyle and dietary habits drives the need
for further investigations. Curcumin is a natural herbal believed to be hepatoprotective.
Aim: To study curcumin as a prophylactic agent in NAFLD rat model.
Material and Methods: thirty rats were allocated into 3 groups. Normal control, high fat diet (HFD) and
the prophylactic groups. HFD regimen was given for 4 months. Curcumin was given as a prophylactic
along with HFD. Livers were harvested and processed for histological study.
Conclusions: Curcumin has an efficient protection and hindering of the development of NASH and could
be recommended in NASH susceptible people.