Postmenopausal Hormone Replacement improves Proteinuria and Creatinine Clearance in Type 2 Diabetes Mellitus and Hypertension

Abstract

Background: Hypertension and diabetes frequently result in renal microvascular damage which progress
to induce proteinuria. Also, menopause is associated with progression of vascular diseases. Aim: determine
if hormone replacement therapy (HRT) can establish renal microvascular damage in type 2 diabetes
mellitus and hypertension which is determined by proteinuria and GFR or not . Patients and methods:
Administration of a cyclic combination of oestradiol and norgestrel orally for 3.5 monthly cycles to 21
postmenopausal women. Results Comparing the baseline values, mean (SD) 24-hour urine protein
excretion decreased from 0.3 g/24h (0.32) to 0.2 g (0.29) (P <0.001) and creatinine clearance improved
from 97-119 mL/min to 99-126 mL/min (P <0.001).it was worth mentioning that HbA1c , post prandial
blood glucose and Random blood sugar were decreased significantly with (P<0.001 ,0.022 and 0.001)
respectively without any additional anti diabetic treatment. Conclusion This study showed that hormone
replacement therapy may reduce proteinuria, and even improve creatinine clearance in diabetic and
hypertensive postmenopausal women.