Ameliorative Potentials Of Ethanolic Leaves Extracts Of Cassia occidentalis And Pithecellobium dulce On Diabetes Associated Metabolic Alterations In Streptozotocin-Induced Diabetic Rats: A Comparative Study

Abstract

A comparative analysis was performed in this study to detect the ameliorative potentials of Ethanolic
leaves extracts (EL) of Cassia occidentalis and Pithecellobium dulce medicinal plants by oral
administration of 200mg/kg bw and 400mg/kg bw individually and in combination on streptozotocininduced diabetic rats. In diabetic rats, the treatment of EL extracts of both plant species (1:1) in
combination of 400 mg/kg bw doses and time following significantly reduced blood glucose level
(101.67± 9.38 mg/dl) and body weight (201.67± 9.38 g) to normal. Individual plant EL extracts also
demonstrated a successful response in diabetic rats at doses of 200 and 400 mg/kg bw in restoring
insulin and hepatic glycogen levels to near-normal levels. In both normal and diabetic rats, total
cholesterol, triglycerides, AST, ALT, carbohydrates metabolic enzymes (Hexokinase, Glucose-6-
Phosphatase, Fructose 1, 6 Bisphospahtes), and antioxidative enzymes (SOD, CAT, and GPx) were
measured. In STZ-diabetic rats, oral administration of EL extracts from both plants in combination
significantly and dose-dependently normalized the above serum and liver parameters (p˂0.05).
Histopathological analysis revealed a protective and restorative effect.