ASSESSMENT OF TRANSCRANIAL DUPLEX IMAGING ABNORMALITIES IN EGYPTIAN CHILDREN WITH SICKLE CELL DISEASE
DOI:
https://doi.org/10.48047/Keywords:
sickle cell disease; transcranial Doppler ultrasound; children.Abstract
Stroke has been recognized as a catastrophic clinical manifestation of sickle cell disease SCD, and efforts
have been made to identify and treat children at the highest risk. TCD screening has modified the natural
history of stroke in children with SCD and emerged as a powerful tool for assessing stroke risk in SCD
patients. This cross-sectional study assessed transcranial Doppler imaging (TCDI) velocities in pediatric
patients with SCD to identify patients at risk for stroke. Forty-six SCD patients were enrolled (23 males
and 23 females), with a median age of 11 years (7.3 - 13.6 years). Thirty-three (71.7%) patients had
homozygous SCD, while 28.3% were sickle β-thalassemia. Forty-two (91.3%) patients had normal TCDI
findings, and 4 (8.7%) patients had abnormal TCDI findings, including 2.2% of patients who had a
conditional TAMMV, while it was low in 6.5% of patients.
