HEPATITIS C VIRUS IGG AND CYTOMEGALOVIRUS IGG PREVALENCE IN PATIENTS WITH DIABETES MELLITUS

Abstract

Background: Hyperglycemia and abnormal glucose metabolism were produced by known pathologic
mechanisms; the etiology of type 2 diabetes mellitus (T2DM) is still enigmatic. Complex interaction of
genetic, metabolic, and environmental factors contributes to T2DM development. The study aimed to
detect of prevalence of HCV and cytomegalovirus in type 2 diabetes mellitus. Patients and methods:
A case-control study done on 95 patients confirmed with T2DM. In addition, 95 apparently healthy
individuals were designated as a control group. The present study was initiated to evaluate seroprevalence of two viral antibodies including (CMV IgG, HCV IgG) beside Hepatitis B surface antigen
(HBsAg) in diabetic patients in comparison to the control group. Results: There was a highly
statistically significant difference between groups according to blood pressure and systolic blood
pressure and mean blood pressure (mmHg). There was statistically significant increase in HCVAb
(IgG) positive patients in diabetic group compared to control group. There was statistically significant
increase in Cytomegalovirus IgG positive patients in diabetic group compared to control group. There
was no statistically significant association between HCVAb (IgG) and Cytomegalovirus IgG in
diabetes group (n=95). Conclusion: There is possible strong association between HCV, and
cytomegalovirus in type 2 diabetes mellitus patients. The rate of seropositive anti-HCV is 2 times
higher in type 2 DM patients than non-diabetic control subjects.