The Relationship Between Serum 25-Hydroxyvitamin D and Clinical and Subclinical Features in Hypertensive Patients with Coronary Artery Disease

Abstract

Background: Vitamin D deficiency increases the risk of many acute and chronic diseases such as type 1
diabetes, cardiovascular disease, several cancers, cognitive impairment, depression, pregnancy
complications, autoimmune disease. This study aims to investigate the relationship between serum 25-
hydroxy vitamin D and clinical and subclinical features in hypertensive patients with coronary artery
disease
Methods: A cross-sectional descriptive was carried out in hypertensive patients with coronary artery
stenosis by coronary.
Results: The serum 25(OH)D level was a statistically significant different between the patients with
different hypertension grades. The level of 25(OH)D was highest in patients with grade I hypertension
and lowest in patients with grade III hypertension. The cut-off point of 25(OH)D in predicting grade IIIII hypertension was < 23.88 ng/ml; AUC = 95.9%, (p < 0.05). Blood cholesterol was negative
correlation with serum 25(OH)D level and the correlation coefficient r = -0.205 with p>0.05. White
blood cells was positive correlation with the serum 25(OH)D level and the correlation coefficient r =
0.366 with p > 0.05. Gensini score was negative correlation with serum 25(OH)D level and the
correlation coefficient r = - 0.150 with p > 0.05.
Conclusion: The serum 25(OH)D level was a statistically significant difference between the patients
with different hypertension grades and there was no correlation with the Gensini score.