CAROTID ATHEROSCLEROSIS AND HEPCIDIN IN CHRONIC KIDNEY DISEASE PATIENTS

Abstract

In 2001, the hepcidin was identified and termed a peptide with anti-microbial effects (1). It consists of
84 amino acids and is known as preprohepcidin. The peptide is subsequently split together to generate a 60-
amino-acid protein called prohepcidin and then processed to make a 25-amino-acid protein called hepcidin.
Prohepcidine's last conversion to hepcidin is catalyzed by furin (2)
. The 25 amino acid peptides are the main form
of human urine, despite the shorter peptides of 20 and 22 amino acids (3)
.