METHOTREXATE AN OLD DRUG WITH NEW TRICKS
DOI:
https://doi.org/10.48047/Keywords:
methotrexate, arthritis, inflammation, alarmin, virus, chikungunya, rheumatoid arthritis, innate immunity, pharmacologyAbstract
Methotrexate (MTX) is the first line drug for the treatment of a number of rheumatic and non-rheumatic disorders. It is
currently used as an anchor disease, modifying anti-rheumatic drug in the treatment of rheumatoid arthritis (RA).
Despite the development of numerous new targeted therapies, MTX remains the backbone of RA therapy due to its
potent efficacy and tolerability. There has been also a growing interest in the use of MTX in the treatment of chronic
viral mediated arthritis. Many viruses—including old world alphaviruses, Parvovirus B19, hepatitis B/C virus, and
human immunodeficiency virus—have been associated with arthritogenic diseases and reminiscent of RA. MTX may
provide benefits although with the potential risk of attenuating patients’ immune surveillance capacities. In this review
