CORRELATION OF SERUM ZINC-ALPHA-2- GLYCOPROTEIN WITH THYROID HORMONE IN NEWLY DIAGNOSED HYPERTHYROIDISM

Abstract

Background: Patients with long-standing untreated hyperthyroidism may develop atrial fibrillation or
heart failure. Treatment of hyperthyroidism requires accurate identification of underlying etiology.
ZAG is known to be a lipid-mobilizing adipokine .It is involved in lipid metabolism in several ways.
The purpose of the study to correlate of ZAG with thyroid hormones (FT3 & FT4) and to illustrate role
of ZAG as a predictor for the outcome of treatment in patients newly diagnosed hyperthyroidism.
Patients and methods: The study included 46 patients divided as 23 in the case group and 23 in the
control group. Carbimazole was given to case group for three months and re-evaluated. All
participants in this study were subjected to full history and thorough clinical examination.
Laboratory investigation including: liver function tests, thyroid function tests, lipogram and fasting
plasma glucose were done. Radiological thyroid scan was investigated. All tested parameters were
performed before and after treartment. Results: There was negative correlation between ZAG and
fasting plasma glucose in hyperthyroidism case group.ZAG was significantly higher in case group than
control group and return to normal values after obtaining normal thyroid function.Thyroid hormone upregulates ZAG production in a dose-dependent manner. This up-regulation of ZAG induced by thyroid
hormone in the liver leading to a significant increase in ZAG circulating levels. The decreased ZAG
levels were significantly correlated with the decreased FT3 even after adjustment for the independent
variables of age, gender and BMI. Conclusion: ZAG levels were positively related with serum free T3
levels after adjusting for age, gender and BMI in patients with newly diagnosed hyperthyroidism both
before and after treatment with carbimazole. ZAG will return to normal values after obtaining normal
thyroid function.