DIAGNOSTIC VALUE OFMICRORNA 499 VERSUS HIGH SENSITIVITY TROPONIN IN EARLY DETECTION OF STELEVATION MYOCARDIAL INFARCTION

Abstract

Background:Early diagnosis and reperfusion of STEMI patients is crucial to preserve the viability of the ischaemic
myocardium, Sowe aimed to prove the diagnostic performance of cardiac enriched microRNA 499 in early diagnosis of
STEMI in comparison to high-sensitivity cardiac troponinT (hs-cTnT).
Subjects and Methods:Circulating concentrations of cardiac troponin and miR-499 measured byquantitative PCR from
50 Egyptian adult patients presented with STEMI to the emergency department of Menufia University Hospitalin a
prospective study conducted during the period from July 2020 to January 2021 then patients population weredivided in two
groups,:Group I: included 25 patient presented early within the first 4 hour of typical chest pain (TCP), Group II: included
25 Egyptian adult patients who presented after 4 hour of TCP,
Results:miR-499 highly increased in 50 Patients with STEMI and it has a positive correlation with peak concentrations
of cTnT, miR-499 was already detectable in the plasma 1 h after onset of chest pain. In patients who presented within 4
h of onset of pain, miR-499 was positive in 88% of patients and hs-cTnT in only 32%.
Conclusion:Circulating miRNAs are powerful markers of acute STEMI,miRNA-499 could be helpfulin early
detectionand diagnosis of STEMI in comparison to hs-cTnT.