EFFECTS OF HYPOXIA-ISCHEMIA ON 25 (OH) VITAMIN D STATUS IN NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY

Abstract

Background: Hypoxic ischemic encephalopathy (HIE) is an important cause of acquired
neonatal brain injury in term newborn infants and it may lead to neonatal death and long-term
disability. Little is known about vitamin D status, immuno-modulatory function, or effects of
hypothermia on vitamin D binding protein (DBP) in neonatal hypoxic-ischemic encephalopathy (HIE).
The current study was aimed to reduce risk of HIE in neonate.
Subjects and methods: A case control study carried out in NICU unit of Zagazig University
Children Hospitals. Total number of cases that met the inclusion and exclusion criteria was 49 full
term neonates with HIE divided according to SARNAT stages: stage I; 20 full term neonates, stage II;
15 full termneonates and stage III; 14 full term neonates, was compared to16 healthy controls. All
cases admitted in NICU were subjected to full history, pregnancy details. Measurement of serum 25
(OH) Vitamin D was performed using ELISA.
Results: There was a statistical significant increase in frequency of hypoxic change in studied
cases compared to control group. there was a statistical significant increase in frequency of hypoxic
change in stage III compared to stage II &I. finally there was a statistical significant increase in
frequency of death among Stage III compare to Stage I & II. All stages of HIE showed statistical
significant increase in frequency of Vit D deficiency comparing to control group stage III had
statistical significant increase in frequency of Vit D deficiency comparing to stage I & II.
Conclusion: Serum 25(OH) vitamin D insufficiency is present in the majority of term HIE
neonates, 25 (OH) Vit D was significantly deficient in stage III more than stage I & II. There was a
statistical significant deficiency Vit D level among dead cases compared to survived cases.