ANTI-HYPERALGESIC EFFECT OF NARINGIN IN CHRONIC CONSTRICTION INJURY
DOI:
https://doi.org/10.48047/Keywords:
Anti-hyperalgesic effects, Randall SelittoAnalgesymeter, Allodynia, Hyperalgesia.Abstract
Chronic neuropathic pain, caused due to damage to the central as well as peripheral nervous system is a debilitating
and prevalent condition affecting 10-18% population. Which had a symptoms like pain, dysaesthesia, paraesthesia,
allodynia, hyperalgesia. Chronic constriction induced neuropathic pain is a rat model-basedexperimentadopting
chronic constriction injury model (Bennett and xie,1988). In this study an attempt was made to test the sensitivity of
the rat to various clinically validated drugs likenaringin(20,40,80mg/kg) as well as gabapentin (100mg/kg),wister
rats of both sexes were used and randallselittoanalgesymeter is used as an experimental toolforpre and post-surgery,
thiopental sodium is used aaanesthesia. Naringin suspensions were prepared just 10 min before the administration.6
rats were taken as subjects for each group. By this study the results suggested that naringin 20,40,80mg has shown
significant decrease in anti hyperalgesic effects and narangin 80mg has exhibited its maxiumum effects compared
with the gabapentin.
