Rationale of PRGF intra-articular injection in temporomandibular disorders management

Abstract

Management of temporomandibular disorder (TMD) still attains researchers’ interest. Recently,
platelets rich plasma (PRP) products especially plasma rich in growth factors (PRGF), has gained
the focus of researchers in musculoskeletal field for being safe autologous substance with
promising outcomes. PRGF is a serum that devoid the white blood cells, RBCs, however, the
platelets were concentrated by 2.84-fold. The regenerative effect of the PRGF and its known
therapeutic rule on injured tissues renders it research worthy topic. At this article we will review
the rationale of PRGF intra-articular injection in TMD patients.