ALUMINIUM NANOPARTICLES TRIGGER SIZE-DEPENDENT PLATELET ACTIVATION: IMPLICATIONS FOR CARDIOVASCULAR RISK

Abstract

Endoprostheses are susceptible to tribological wear and biological processes that result in the 
release of particles, including aluminium nanoparticles (Al NPs), which can enter the 
bloodstream. The toxic effects of these nanoparticles on platelets have not been thoroughly 
investigated. This study aimed to assess the influence of Al NPs on human platelet function 
using an innovative quartz crystal microbalance with dissipation (QCM-D) approach, 
alongside various assays such as light transmission aggregometry, flow cytometry, optical 
microscopy, and transmission electron microscopy