DEVELOPMENT OF SCI RAT MODEL USING IMAPCT DEVICE AND ASSESSMENT OF ANIMAL BEHAVIOUR

Abstract

An zebrafish of degenerative diseases is necessary for determining the etiology of both the
loss, studying cord repair, and supporting in the development of new therapeutic methods. the
development of a scaled randomized trauma concept for nervous system damage using air
input devices (SCI) and analysis of animal behaviour were the main focuses of this study.
The cord's dorsal side suffered a contusive damage. According to the impact velocity, three
trauma groups were established (IV). Six people in a control group merely got laminectomy.
IVs were 1.5 m/sec, 2.0 m/sec, and 3.5 m/sec for Groups 1 (n=10), 2 (n=10), and 3 (n=10),
respectively. Functional evaluations were conducted up to 14 days after the injury. Both the
control group and each trauma group had significant behavioural abnormalities. Following
injuries, all trauma groups displayed considerable functional impairment, although at varying
rates of functional recovery (Fig. 3). The findings imply that the rat method is particularly
useful for assessing the consequences of applied stress and continuously multiplies injury.
Overall depth of the designate lesion became apparent as the flow rate and shock progressed.