A study on evaluate the utility of 3D vena contract a area in assessing the severity of MR

Abstract

Aim: To study the levels of NT-pro BNP and its correlation with various echocardiographic parameters
including 3D vena contract a width in patients with MR.
Methodology: The study was done prospectively in the department of cardiology, Kamineni Academy
of Medical Sciences, between September 2019-August 2020.74 Patients diagnosed with primary mitral
regurgitation and who were treated at KAMS during study period were included.
Results: We observed that moderate to severe mitral regurgitation prevalence increases with age. Mitral
regurgitation was almost equally distributed in both males (n = 36) and females (n= 38). In our study we
observed that CRHD was the most common cause of organic mitral regurgitation. In echocardiography,
increasing vena contract a width and increasing PISA correlated to increased levels of plasma NT-pro
ANP and NT-pro BNP. No other correlation was found between measures on MRI, echocardiography
and natriuretic peptides. We also observed that there was a significant correlation between 3D VC and
2D VC in all patients of mitral regurgitation with central jet and in patients of mild MR with eccentric
jet. However, correlation is better in central jets compared to eccentric jets in moderate MR (r =0.956 vs
r = 0.774).
Conclusion: This study showed that NT-proBNP measurement has the same sensitivity and specificity
as echocardiographic indices and may be used as a hormonal factor for the evaluation of patients with
mitral regurgitation in combination with echocardiography. Myocardial performance index combined
with NT-proBNP measurement may be helpful in detection of subclinical impairments in left ventricle
functions.